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Symbol
Name
ID

Notch3
notch 3
MGI:99460

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Stroke

Lacunar stroke

Pseudobulbar paralysis

Abnormality of visual evoked potentials

Hydrocephalus

Recurrent subcortical infarcts

Leukoencephalopathy

Chiari malformation

Chiari type I malformation

Arachnoid cyst

Dural ectasia

Meningocele

Tethered cord

Syringomyelia

Benign neoplasm of the central nervous system

Hemiplegia/hemiparesis

Hemiparesis

Psychosis

Perseverative thought

Atypical behavior

Abulia

Personality changes

Memory impairment

Dementia

Subcortical dementia

Intellectual disability

Obstructive sleep apnea

Gait disturbance

Migraine

Global developmental delay

Motor delay

Peripheral neuropathy

Seizure

Disease(s) Associated with NOTCH3

CADASIL 1

infantile myofibromatosis

lateral meningocele syndrome

Mouse Phenotypes		nervous system phenotype	increased susceptibility to ischemic brain injury	increased cerebral infarct size	hydrocephaly	brain lesion	gliosis	decreased prepulse inhibition
Availability	Mouse Genotype	nervous system phenotype	increased susceptibility to ischemic brain injury	increased cerebral infarct size	hydrocephaly	brain lesion	gliosis	decreased prepulse inhibition
	Notch3^{Gt(PST033)Byg}/Notch3^{Gt(PST033)Byg}	*
	Notch3^hpbk/Notch3^hpbk
	Notch3^{tm1.1(KOMP)Vlcg}/Notch3^{tm1.1(KOMP)Vlcg}
	Notch3^tm1.1Dwr/Notch3^tm1.1Dwr
	Notch3^tm1.1Dwr/Notch3⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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